Medscape March 27, 2024
The size of the human brain has increased over time, a new finding that may help explain a previously reported decline in incident dementia.
A secular trends analysis using brain imaging data from the long-running Framingham Heart Study, revealed an increase in intracranial volume (ICV), cortical gray matter, white matter, and hippocampal volumes, as well as cortical surface area in people born in the 1970s vs those born in the 1930s.
“We hypothesize that the increased size of the brain will lead to increased ‘reserve’ against the diseases of aging, consequently reducing overall risk of dementia,” Charles DeCarli, MD, director of the Alzheimer’s Disease Research Center and Imaging of Dementia and Aging Laboratory, Department of Neurology and Center for Neuroscience,...
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