Eric Topol December 14, 2024

What Is Being Missed By Relying on Population-Based Reference Values

A Complete Blood Count (CBC) is by far the most frequent lab test obtained, with about 2 million per day or 500 million per year in the United States. All these results are conveyed to clinicians and patients as to being “normal” or “abnormal” indexed to a one-size-fits-all, population-based average reference values.

An important new study this week published in Nature by Brody Foy and colleagues shed new light on the importance of personalized reference values—intra-individual variation— and the multitude of data and insights that can be gleaned from this way if analyzing one’s CBC data. In this edition of Ground Truths, I’m going to review the main results and...

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