MedPage Today August 31, 2024
— And two aren’t in the standard cardiovascular risk prediction tool
LONDON — A combination of three factors — high-sensitivity C-reactive protein (hsCRP), LDL cholesterol, and lipoprotein(a), or lp(a) — independently predicted cardiovascular disease over 30 years in women who were initially healthy, according to an analysis of the Women’s Health Study.
Each of the three factors predicted the 30-year risk for both coronary heart disease and stroke, and each contributed to overall risk prediction, but the greatest spread for risk was in models that incorporated all three biomarkers together.
Elevation in 30-year risk from being in the top versus bottom quintile was 70% for hsCRP, 36% for LDL cholesterol, and 33% for lp(a) after adjustment for covariates. While the...
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