Medscape December 1, 2025
Marilynn Larkin

The World Health Organization (WHO) has released its first guideline on the use of GLP-1 therapies for treating obesity in adults.

Obesity currently affects more than 1 billion people globally — a number projected to double by 2030, according to WHO. The organization defines obesity as having a BMI of 30 or higher in adults aged more than 19 years.

The new guideline “recognizes that obesity is a chronic disease that should be treated with comprehensive and lifelong care,” Francesca Celletti, MD, PhD, WHO senior adviser on obesity, told Medscape Medical News. It was developed in response to requests from WHO member states, and it’s a key deliverable under the WHO acceleration plan to stop obesity.

“The arrival of these...

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