Medscape February 10, 2025
Aude Lecrubier

Beyond the well-known mRNA vaccines for COVID-19, therapeutic RNAs are emerging in diverse medical fields, including cardiology, ophthalmology, infectious diseases, and hepatology. However, could they also hold promise in rheumatology?

During a session at the recent French Congress of Rheumatology (SFR 2024) in Paris, France, Florence Apparailly, PhD, from the Centre Hospitalier Universitaire de Montpellier, Montpellier, France, affirmed their potential, describing these small genetic molecules as “a promising solution in rheumatology.”

RNA therapies offer the key advantage of precisely targeting genes or proteins involved in the inflammatory and autoimmune pathways. This specificity could enable personalized treatments while minimizing the side effects often seen with conventional therapies that act more broadly.

Types of Therapeutic RNA Currently Available

  • Messenger RNAs:...

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