MedPage Today April 7, 2024
— Weight and symptoms improved in STEP-HFpEF DM trial
ATLANTA — Weight loss and heart failure benefits with semaglutide (Wegovy) extended to patients with obesity-related heart failure with preserved ejection fraction (HFpEF) who have type 2 diabetes, the STEP-HFpEF DM trial showed.
A 2.4-mg dose of the GLP-1 receptor agonist improved HF-related symptoms and physical limitations as measured with the Kansas City Cardiomyopathy Questionnaire-Clinical Summary Score compared with the change over 1 year on placebo (13.7 vs 6.4 points on the 100-point KCCQ-CSS scale, P<0.001).
Patients also lost 6.4 percentage points more body weight with semaglutide over that period (−9.8% vs −3.4%, P<0.001), reported Mikhail N. Kosiborod, MD, of Saint Luke’s Mid America Heart Institute and the University of Missouri-Kansas...
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