Hospital & Healthcare Management December 22, 2025
Real-world evidence represents clinical data collected outside traditional controlled trial environments, derived from sources including electronic health records, insurance claims databases, disease registries, wearable devices, and patient-reported outcomes.
Key Takeaways
Traditional randomized controlled trials, while scientifically rigorous, often investigate medications under carefully controlled conditions involving selected patient populations that may not represent actual clinical practice. Trial protocols specify restrictive inclusion/exclusion criteria, closely monitor participants, and follow standardized protocols that differ substantially from typical clinical settings. While this controlled approach provides scientifically robust efficacy data, it generates limited information regarding how treatments actually perform across diverse patient populations under real-world conditions. Real-world evidence addresses this limitation by documenting treatment performance in everyday clinical practice, revealing treatment effectiveness, safety patterns, and optimal...
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