News-Medical.Net January 2, 2025
Columbia University Irving Medical Center

New work by Columbia researchers has turned a textbook principle of genetics on its head and revealed why some people who carry disease-causing genes experience no symptoms.

Every biology student learns that each cell in our body (except sperm and eggs) contains two copies of each gene, one from each parent, and each copy plays an equal part in the cell.

The new study shows that some cells are often biased when it comes to some genes and inactivate one parent’s copy. The phenomenon was discovered about a decade ago, but the new study shows how it can influence disease outcomes. The Columbia researchers looked at certain immune cells of ordinary people to get an estimate of the phenomenon...

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