Health Affairs January 22, 2026
Editor’s Note
This article is the latest in the Health Affairs Forefront featured topic, “Health Policy at a Crossroads,” produced with the support of the Commonwealth Fund and the Robert Wood Johnson Foundation. Articles in this topic offer timely analysis of regulatory, legislative, and judicial developments in health policy under the Trump-Vance Administration and the 119th Congress.
Looking at the photos of baby KJ Muldoon playing at home with his family, happy and thriving, it is hard to imagine that he was born with a rare genetic urea cycle disorder typically associated with either liver transplant or death. Instead, in February 2025, KJ was the first person to receive an investigational personalized gene-editing treatment customized to his specific genetic variant.
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