HIT Consultant June 20, 2025
Natalie Schibell, VP of Market Strategy and Communications at Aetion,

Real-world evidence (RWE) has become central to evaluating therapies, medical products, and health interventions—providing insight into how they perform outside controlled clinical trials. As healthcare systems seek more timely, representative, and cost-effective approaches to evidence generation, real-world data (RWD) is increasingly used to inform regulatory decisions, guide clinical practice, and shape health policy.

As RWE gains traction, fundamental questions remain: How do we ensure it’s reliable? How do we define quality? And how do we use it consistently across systems that were never built for it? The industry agrees on RWE’s importance—but not yet on how to evaluate or integrate it.

In 2025, RWE stands at a crossroads. The infrastructure to support it is growing, but the rules of engagement—especially...

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