Health Affairs October 7, 2025
Ana Santos Rutschman, Jacqueline Penrod

US vaccine policy is rapidly changing—and increasingly pitting federal and state vaccine regulators against one another. Most recently, states on both coasts have formed regional networks with the explicit purpose of countering federal guidelines in the vaccine space. These recent events present new challenges for vaccine federalism, as well as for public health federalism in general. We contrast the differences between the traditional model of vaccine federalism and the emerging paradigms introduced by the ongoing shifts in vaccine policy. We then consider the long-term implications of the intensifying rift between federal and state vaccine regulators.

Longstanding Vaccine Federalism

The traditional model of vaccine federalism can be regarded as complementary and generally consonant. As with other public health-related matters, federal and...

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