NEJM August 28, 2024
Lawrence O. Gostin, J.D., Ashish K. Jha, M.D., M.P.H., and Alexandra Finch, L.L.M

On August 14, 2024, the director-general of the World Health Organization (WHO) declared mpox in the Democratic Republic of Congo (DRC) and neighboring countries to be a Public Health Emergency of International Concern (PHEIC) under the 2005 International Health Regulations (IHR) — the WHO’s highest-level alert. The previous day, the Africa Centers for Disease Control and Prevention (Africa CDC) declared a Public Health Emergency of Continental Security (PHECS) — the organization’s first-ever declaration of a regional health emergency. This regional declaration and the WHO’s early response — issued without waiting for mpox to affect high-income countries — could offer a historic opportunity to mobilize lifesaving resources according to the principles of solidarity and equity.

Mpox clade I has been...

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