Psychiatric Times November 16, 2023
James Phelps, MD

In this Special Report, let’s re-evalute depression.

SPECIAL REPORT: TREATMENT-RESISTANT DEPRESSION

The goal of this Special Report is to help you manage treatment-resistant depression (TRD) as best as possible while minimizing harm. This requires first recognizing the kind of depression with which your patient presents to ensure the treatment strategy is the most appropriate.

As none of the historical terms (eg, neurotic, psychotic, melancholic) or DSM terms (eg, dysthymia, major depression, mixed features) are distinct biological entities, let us turn to etiology for a better understanding and a refined diagnosis. In my experience, there are 5 kinds of common clinical depression, worth differentiating in that they call for varying treatments (Table). This list is not exhaustive, but the 5 types...

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