Eric Topol June 22, 2025

A rapid expansion of new discoveries and knowledge lays the foundation for a new era in medicine

We’ve known about the gut-brain axis for decades but there has recently been an unprecedented jump in our knowledge base that has transformed our expectations for its preeminence. In this edition of Ground Truths I’m going to review some of the recent advances that are shaping the field, particularly for a new era of gut hormones in medicine. But that’s only part of the expansion!

Background

To start with I’m going to simplify things because if I tried to diagram all the ways the gut and brain interact bidirectionally, it would be hard to follow. So here is my reductionist representation.

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