Forbes October 6, 2022
William A. Haseltine

This article is part 2 of a series on next-generation mRNA vaccines. The first installment can be read here.

The unprecedented speed with which we developed vaccines to help us control and curb the Covid-19 pandemic is in large part thanks to years of research on messenger RNA (mRNA) technology. As impressive as this effort has been, and as effective as the vaccines are, it by no means marks the pinnacle of mRNA technology; on the contrary, this initial success has emboldened further innovation, and the next-generation of mRNA vaccines is beginning to take shape. Self-amplifying mRNA (saRNA) represents one such advancement. What are self-amplifying mRNA vaccines and how do they compare to conventional mRNA vaccines? What are the benefits...

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