Medical Xpress August 13, 2024
A new type of degenerative brain disease, limbic-predominant age-related TDP-43 encephalopathy (LATE), was recognized just a decade or so ago, and remains relatively unknown.
In the disease, the TDP-43 protein accumulates particularly in the limbic brain regions, which are also affected in the early stages of Alzheimer’s disease. Accordingly, symptoms of LATE are similar to those of early Alzheimer’s, but typically progress more slowly and are milder.
University of Helsinki researchers have conducted the first study exploring the prevalence of LATE in a population-based Finnish autopsy dataset encompassing 300 Finns over the age of 85.
LATE was found to be very common. Changes associated with the disease were identified in at least every second individual over the age of 85....
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