STAT July 29, 2024
The human body works hard to prevent outside substances from entering the brain — which makes it a challenge to get drugs into the brain to treat neurological diseases. A study published today in Nature Microbiology opens the door to a potential clever solution, showing how Toxoplasma gondii, a parasite that is able to cross the blood-brain barrier, can be engineered to treat a brain development disorder in mice.
Shahar Bracha, a postdoctoral fellow at the Massachusetts Institute of Technology, and colleagues engineered the parasite to make and secrete...