STAT March 27, 2024
One of the indignities of getting older is the way your body’s defenses against microbes begin to break down, leaving you extra vulnerable to infection. Researchers studying the ways these systems change with age refer to them collectively as “immunosenescence,” or, more poetically, the “twilight of immunity.” But even as scientific understanding of the phenomenon has grown over the past decade, the forces driving it remain murky.
One theory is that it all starts in the bone marrow, where a primitive reserve of stem cells replenishes the ranks of blood and immune cells to the tune of about 500 billion new cells every day. Some of these hematopoietic stem cells, or HSCs, are more likely to become long-lived stewards of...
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