Eric Topol January 21, 2026

Two new studies add to a remarkable body of evidence for benefit

Last April I wrote a Ground Truths entitled “The Shingles Vaccine and Reduction of Dementia.” At the time many were unaware of this unanticipated relationship based on 2 large natural experiments. Two new studies this week have advanced our understanding about the potential biological impact of the Shingles vaccine, independent of its effects for preventing Shingles or direct action vs. herpes zoster virus and reinforced its protection from dementia, ~80% of which is attributable to Alzheimer’s disease. In this post I won’t get into the details of what I previously wrote (please link back for more perspective), but instead devote the text to the new findings. I’ll come...

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