Inside Precision Medicine March 14, 2025
Researchers from St. Jude Children’s Research Hospital and the University of Wisconsin-Madison have developed Spotiphy, an AI-driven computational tool that enhances spatial transcriptomics by achieving both single-cell resolution and whole-genome coverage. Published in Nature Methods, the study showcases Spotiphy’s ability to reconstruct high-resolution gene expression maps, unlocking new insights into neurodegenerative diseases like Alzheimer’s and improving cancer research.
Overcoming the tradeoff in spatial transcriptomics
Spatial transcriptomics (ST) is a powerful technique that captures gene expression within intact tissues. However, existing methods require a tradeoff:
- Sequencing-based ST covers the entire genome but has low resolution, grouping multiple cells into one data point.
- Imaging-based ST offers single-cell resolution but captures only a limited number of genes.
To address this, Spotiphy...
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