AXIOS July 1, 2024
Tina Reed

Certain first-line antidepressant medications are more likely than others to cause weight gain, according to a study in the Annals of Internal Medicine.

Why it matters: Drug-related weight gain may deter some patients from starting or adhering to their prescriptions.

What they found: The study led by Harvard Medical School looked at electronic health record data of 183,118 new antidepressant users from eight U.S. health systems between 2010 and 2019. Patients were between the ages of 21 and 79 years old.

  • They compared weight gain among patients prescribed several different first-line antidepressants and those taking sertraline, also known under the brand name Zoloft, which is the most commonly prescribed antidepressant.
  • They found users of escitalopram (Lexapro) and paroxetine (Seroxat)...

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