Medical Xpress September 23, 2024
Experts from the University of of Dundee’s Centre for Targeted Protein Degradation (CeTPD), working with Boehringer Ingelheim scientists, have developed a breakthrough small-molecule drug, a “protein degrader.”
KRAS is the most mutated gene in cancer with mutations occurring in 17%–25% of all cancers, affecting millions of patients worldwide. It plays a crucial role in tumor growth, as it is important for driving uncontrolled proliferation of tumor cells.
Targeting KRAS function is a primary focus of cancer drug discovery. However, currently approved treatments can only address one of many KRAS gene mutations, called G12C, leaving more than half of patients with cancers driven by KRAS without a targeted treatment option.
The molecule ACBI3 developed by multi-disciplinary teams in the laboratory of...
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