Sinaptica’s Novel Approach to Alzheimer’s Leverages Electrical Brain Stimulation

Using precision neuromodulation therapy to electrically stimulate the brain, Sinaptica Therapeutics is able to slow the progression of Alzheimer’s, with impressive Phase 2 results.

Origin Story

Giacomo Koch, MD, PhD, and Emiliano Santarnecchi, PhD, have been working together for over a decade on issues related to Alzheimer’s and neuromodulation. At the Santa Lucia Foundation in Rome, Dr. Koch, a practicing neurologist and neuroscientist, works with Alzheimer’s patients as well as conducting research in his lab, while on the other side of the Atlantic, Dr. Santarnecchi – who directs the Precision Neuroscience lab at Harvard-MGH – uses neuroimaging and electrophysiology to develop diagnostic and therapeutic solutions for Alzheimer’s patients.

Their collaboration...