Medscape June 29, 2023
Patients with cancer are increasingly having tumor DNA sequenced: The technology has improved, prices have dropped, and such sequencing can identify a new treatment approach. But some investigators question whether every cancer patient can benefit.
The technology has evolved since the establishment of The Human Genome Project, hailed as a triumph of science when the “final” sequence of human DNA and its roughly 3.2 billion nucleotide bases was published in six papers in the journal Science in 2002. That was carried out using an enhanced version of a DNA sequencing method known as Sanger sequencing.
As the name implies, DNA sequencing is a method for determining the exact order of nucleotides, or “bases” in a strand of DNA. Sanger...
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