Medical Xpress October 8, 2024
Lewy bodies are a hallmark of Parkinson’s disease (PD) and other related neurological conditions. Understanding why and how they develop is critical to developing better treatments.
A study from The Neuro (Montreal Neurological Institute-Hospital) of McGill University, in collaboration with its Early Drug Discovery Unit, has recreated the growth of Lewy bodies in human neurons and followed their formation to gain important insight into why and how they form. The scientists published their results in the journal Nature Neuroscience on Oct. 8, 2024.
Critically, they find that immune challenge is important for this process, identifying a previously unknown link between the immune system and neurological disease.
Lewy bodies are thought to result from the buildup of misfolded proteins in neurons....
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