RPM Shows Promise for Safer, More Feasible Outpatient Bispecific Administration

Tara M. Graff, DO, director of clinical research at Mission Cancer + Blood at the University of Iowa Health Care, spoke about the real-world application of remote patient monitoring (RPM) to support outpatient step-up dosing of bispecific antibodies, highlighting the balance between safety, patient selection, and operational feasibility. An abstract from ASH 2025 underscores the potential for RPM to enable outpatient administration while mitigating the need for prolonged inpatient monitoring, but Graff emphasized that the approach is not universally appropriate.

Patient selection is critical. Older, frail, or high-risk patients—particularly those unfamiliar with...