Medical Xpress September 5, 2024
Scientists at Cognigenics have made a significant advance in the field of neuroscience and mental health treatment. Their research, published in Genomic Psychiatry, demonstrates that a new RNA-based therapy called COG-201 can enhance memory and reduce anxiety in animal models.
COG-201 uses short hairpin RNA (shRNA) to target and reduce the expression of the serotonin 5-HT2A receptor in the brain. This receptor plays a crucial role in regulating mood, anxiety, and cognitive functions. By decreasing its expression, the researchers observed notable improvements in memory and reductions in anxiety-like behaviors in both mice and rats.
“Our findings suggest that COG-201 could offer a new approach to treating conditions like mild cognitive impairment and anxiety disorders,” said Dr. Troy T. Rohn, lead...
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