Medical Xpress April 25, 2025
A common diabetes drug can reduce the pain of people with knee osteoarthritis and overweight or obesity, possibly delaying the need for knee replacements, Monash University-led research has found.
Metformin, which is commonly prescribed to treat type 2 diabetes, reduced knee arthritis pain over six months in a clinical trial published in JAMA.
The randomized clinical trial looked at whether metformin, compared to a placebo, reduced knee pain in patients with symptomatic knee osteoarthritis (knee OA) and overweight or obesity.
The research was performed entirely as a community-based study using telehealth. Some of the 107 participants with pain from knee osteoarthritis (73 women and 34 men), who had a mean age of 60, took up to 2,000 mg of metformin...
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