Medical Xpress January 22, 2026
Researchers at Moffitt Cancer Center have developed a new way to predict how cancer cells evolve by gaining and losing whole chromosomes, changes that help tumors grow, adapt and resist treatment. In a new study, scientists describe a computational approach called ALFA-K that uses longitudinal, single-cell data to reconstruct how cancer cells move through different chromosome states over time and identify which configurations are favored by evolution.
The findings show that cancer evolution is not random. Instead, tumors follow measurable rules shaped by chromosome configuration, evolutionary dynamics and treatment-related stress, offering a new framework for anticipating how cancers change and respond to therapy.
The paper is published in the journal Nature Communications.
Noemi Andor, Ph.D., corresponding author and associate member...
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