Inside Precision Medicine November 12, 2024
Targeted protein degradation is a method that selectively eliminates disease-causing proteins. Scientists at the University of California, Riverside (UCR), are now using this method to pave a way for new cancer therapies. The scientists have developed a “molecular crowbar” strategy to identify protein degraders that target Pin1, a protein involved in pancreatic cancer development. The scientists designed agents that bind tightly to Pin1 and are designed to cause its destabilization and cellular degradation. The degraders which were made in the lab, act like “molecular crowbars” that open up the structure of Pin1, rendering it less stable.
The study is published in the Proceedings of the National Academy of Sciences and led by Maurizio Pellecchia, PhD, a professor of biomedical sciences...
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