Health Affairs February 18, 2020
Monika Schneider, Nicholas R. Harrison, Mark B. McClellan

In 2019, the Centers for Disease Control and Prevention (CDC) released an updated report on Antibiotic Resistance Threats in the United States, which includes a list of pathogen threats categorized as urgent, serious, and concerning. The new numbers are sobering: Nearly three million Americans contract antibiotic-resistant infections every year, and more than 35,000 people die as a result. Most alarming, the number of antibiotic-resistant infections that are considered urgent threats has increased since the 2013 publication of this report.

Part of the reason the number of pathogen threats has grown is because our current antibiotics are increasingly ineffective in combatting infections, and few new drugs are being developed. Antibiotic approvals rely on specific clinical trial requirements and narrow patient...

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