Eric Topol February 19, 2024
A new multi-ancestry report on 10 conditions moves us forward
“The potential impact of polygenic risk score (PRS)-based risk assessment in clinical practice is substantial”—eMERGE investigators
Today in Nature Medicine, Niall Lennon and 80 co-authors published an important paper, advancing the clinical case to use polygenic risk scores for determining high-risk across 10 common conditions.
Established in 2007, the eMERGE (Electronic Medical Records and Genomics) multicenter consortium has, in recent years, been working on improving, validation, and clinical implementation of polygenic risk scores. That includes expanding data inputs to achieve diverse ancestry and ethnicity, assessing performance, developing threshold for high-risk, selecting which PRS conditions have high performance and actionability for high-risk individuals, and creating reports for individuals so they can...
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