Medical Xpress March 3, 2021
Randomized clinical trials are the undisputed gold standard for determining whether a treatment protocol is effective for a specific disease or condition.
But while seen as the best way to determine how effective a drug or vaccine is, RCTs, as they are known, aren’t designed to capture the nuances that distinguish how individual patients respond.
A recent paper in JAMA Pediatrics recommends that pediatricians and other providers explore the concept of single case, or N-of-1 experimental designs, as they are also known, the purpose of which is to apply experimental methods to caring for individual patients in challenging cases.
“It has been known for some time that there is considerable heterogeneity of treatment effects in randomized trials, with the trial...
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