Clinical Trials Arena August 5, 2025
Discontinuation rates in pediatric trials remain high, reflecting logistical and clinical obstacles. To overcome these hurdles, clinical research organizations can assist – re-thinking pediatric trial design to facilitate more effective child-centric research
Pediatric clinical trials are often designed according to templates established for adults. Yet there are notable differences between adults and children across physiological, developmental, psychological, and pharmacological factors. Consequently, pediatric trials have high discontinuation rates across key research areas. Children differ from adults from a physiological, developmental, psychological, and pharmacological standpoint. As a result, they are far more complex than ‘small adults’ and, from a clinical perspective, there is a significant need for pediatric studies.
Children might metabolise medications at different rates, resulting in sub-optimal therapy, unexpected responses,...
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