Inside Precision Medicine August 2, 2024
A large study of Parkinson’s disease genetics led by CENTOGENE, and the University of Rostock in Germany, shows approximately 15% of all cases of the disease are driven by genetic variants.
As reported in the journal Brain, the researchers also confirmed that around 90% of individuals with a genetic form of the disease had mutations in the LRRK2 or GBA1 genes.
“Estimates of the spectrum and frequency of pathogenic variants in Parkinson’s disease in different populations are currently limited and biased. Furthermore, although therapeutic modification of several genetic targets has reached the clinical trial stage, a major obstacle in conducting these trials is that Parkinson’s disease patients are largely unaware of their genetic status and, therefore, cannot be recruited,” write...
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