Fortune August 22, 2024
Drugs like Ozempic and Wegovy—also known as glucagon-like peptide-1 (GLP-1) or semaglutide medications—have been linked to increased suicidal thoughts, says a new study published in JAMA Network Open on Aug. 20.
“A detected signal of semaglutide-associated suicidal ideation warrants urgent clarification,” the academic researchers noted in the study.
Using an expansive World Health Organization database of reported individual adverse reactions to medications, they conducted a disproportionality analysis of GLP-1 RAs semaglutide and liraglutide, looking for observations of suicidal thoughts, and found such thoughts to be greater than expected.
What they found was a 45% greater rate of reports of suicidal thoughts associated with semaglutide than with all the other drugs in the database.
Mixed findings in semaglutide studies
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