STAT November 16, 2023
In 1993, I published “Listening to Prozac,” a book that grew out of my clinical experience prescribing what was then a new class of medications, ones thought to moderate depression through their effect on the way that the brain handles the neurotransmitter serotonin.
Some of my patients had reported marked favorable reactions to the drugs — first Prozac and, soon after, Zoloft. On medication, the patients were more confident, less anxious, and less pessimistic. They felt better than they had even before the episode of whatever it was that we were treating, depression or increased obsessionality. One patient said that she was herself at last, as if, absent the formulation of the new drug, she would never have been herself....
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