STAT August 2, 2024
John P. Moore

Where and when the Covid-19 pandemic began — in Wuhan, China in late 2019 — is well known. How it began is a matter of heated controversy. There are two competing hypotheses, one of which is hindering the process of scientific discovery and could hold back the development of vaccines and other antiviral agents in the U.S.

The zoonosis hypothesis proposes that SARS-CoV-2, the virus that causes Covid-19, was naturally transmitted from an animal to one or more humans in a so-called wet market in Wuhan selling fresh produce, meat, fish, and live animals. The lab leak hypothesis posits that the virus was modified (possibly through gain of function maneuvers), or even created, in the Wuhan Institute for Virology (WIV)...

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