Forbes January 20, 2026
Genetic variants can act together, inhibit one another or trigger a whole chain of events, making the genetic puzzle far more complex than single-gene models suggest. New research has found that two genetic mutations, each individually harmful, can sometimes combine to restore normal protein function. This is just one example of a broader phenomenon: no gene acts alone. Rather, our health is shaped by a vast puzzle of interacting genes and genetic variants.
Sometimes genes work together, sometimes they inhibit each other and often, a whole chain of events must unfold before a genetic predisposition manifests. That’s why no single gene is fully dominant, and why our understanding of genetic risk must consider the many factors at play. This concept...
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