ICT&health April 9, 2025
Physicists at TU Delft have developed a new microscopy technique using ultrasound. This makes capillaries and cells in living organs visible. Previously, it was not possible to image this properly. Key to this innovation in ultrasound – a method called Nonlinear sound sheet microscopy – was the discovery of a sound-reflecting probe developed at Caltech’s Shapiro Lab.
Heiles explains that this probe is a nanoscale gas-filled vesicle that lights up in ultrasound images making cells visible. ‘These vesicles have a shell of proteins and we can design them so that we can tune their brightness in images. We have used these gas vesicles to track cancer cells,’ Heiles adds. The research has been published in Science.
Ultrasound is one of...
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