Medical Xpress November 12, 2024
Scientists at deCODE genetics have published a study in Nature Communications that sheds light on how body mass index (BMI) influences the risk of various diseases that are comorbid with obesity. The study, which used genetic data from Iceland and the UK Biobank, looked at whether disease risks associated with BMI-related sequence variants are explained completely or partially by their effect on BMI.
The results showed that for some conditions, such as fatty liver disease, glucose intolerance, and knee replacement, the genetic link to disease disappeared when BMI was taken into account. For other conditions, like type 2 diabetes, heart failure, and stroke, the effects were largely reduced but...
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