STAT August 4, 2022
When coronary arteries are blocked, starving the heart of blood, there are good medications and treatments to deploy, from statins to stents. Not so for heart failure, the leading factor involved in heart disease, the top cause of death worldwide.
“It’s what’s on death certificates,” said cardiologist Christine Seidman.
Seidman has long been interested in heart muscle disorders and their genetic drivers. She studies heart failure and other conditions that affect the myocardium — the muscular tissue of the heart — not the blood vessels where atherosclerosis and heart attacks come from, although their consequences are also felt in the myocardium, including heart failure.
With her colleagues at Brigham and Women’s Hospital and Harvard Medical School, she and a long...
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