Bio-IT World February 7, 2024
In a big advance for precision medicine, researchers in Australia have developed a genetic biomarker of people’s response to sodium reduction. It is often but not always the case that modifying sodium levels lowers blood pressure by reducing the fluid volume of blood in the cardiovascular system, and knowing in advance how patients will respond could help eliminate the “treatment odyssey” that many of them are experiencing, according to Murray Cairns, Ph.D., professor at Hunter Medical Research Institute and the University of Newcastle (Australia).
The “pharmagenic enrichment score” (PES) under investigation represents a new and scalable diagnostic approach where the assessment of polygenic risk is constrained to the biology of a drug’s mechanism of action, explains...
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