Inside Precision Medicine February 21, 2025
A team from Europe has created mouse models of liver cancer that could help overcome one of the biggest obstacles in doing drug research on this disease—being able to test against subtypes.
The team generated a suite of genetically-driven immunocompetent in vivo and matched in vitro hepatocellular carcinoma (HCC) models they say represent multiple features of human HCC, including clonal origin, histopathological appearance, and metastasis. They also integrated transcriptomic data from the mouse models with human HCC data and identified four common human–mouse subtype clusters.
The report appeared in Nature and the lead author is Miryam Müller, PhD, of the Cancer Research UK Scotland Institute, Glasgow.
HCC is the most common form of primary liver cancer and a leading...
Today's Sponsors
Today's Sponsor