Eric Topol June 21, 2024

Four new studies illuminate biologic underpinnings + an update

We’ve been struggling to understand what gets off the track with the immune response in people with Long Covid. Two new reports have shed considerable light on this complexity. Two others inform us about the protection from acute Covid and the importance of vaccination to protect against neurologic sequelae.

Transferring Antibodies from People to Mice

Recently, Jeroen den Dunnen and colleagues at Amsterdam Institute for Infection and Immunity preprint published a study giving IgG antibodies from people with Long Covid (LC) and healthy controls to mice. That induced mice with pronounced hypersensitivity (quicker reaction time) and reduced locomotor activity, related to the proteome profiles of the individuals with LC.

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