News-Medical.Net December 3, 2025
A landmark review published today in Genomic Psychiatry challenges researchers to fundamentally reconsider how the field measures and conceptualizes biological aging. Dr. Dan Ehninger, who leads the Translational Biogerontology Laboratory at the German Center for Neurodegenerative Diseases, and Dr. Maryam Keshavarz present a systematic analysis arguing that widely used proxies for aging, including lifespan extension, epigenetic clocks, frailty indices, and even the celebrated hallmarks of aging framework, may conflate genuine modifications of aging trajectories with simpler age-independent effects on physiology.
The lifespan paradox: When living longer does not mean aging slower
Perhaps the most counterintuitive finding emerges from the authors’ cross-species analysis of what actually kills organisms as they age. In humans, cardiovascular disease consistently accounts for 35 to 70...
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