Medical Xpress March 21, 2025
Almost half of patients diagnosed with depression classify as being “treatment-resistant” as new research suggests that many don’t respond to multiple antidepressant options.
The study, published in the British Journal of Psychiatry, was led by academics from the University of Birmingham and Birmingham and Solihull Mental Health NHS Foundation Trust. The study found that 48% of patients whose electronic health care records reported a diagnosis of depression had tried at least two antidepressants, and 37% had tried four or more different options.
Treatment-resistant depression (TRD) is typically defined as a form of depression that isn’t effectively managed after a patient tries two different antidepressants. There are currently few guidelines for treating TRD.
Patients who experience TRD were also invited to...
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