Bio-IT World November 14, 2024
Investigators at Weill Cornell Medicine have combined several powerful technologies to reconstruct how cancer spreads from the prostate to metastatic sites elsewhere in the body. Bioluminescence imaging, CRISPR/Cas9-based barcoding, and innovative computational methods for tracing the movement of cancer from tissue to tissue were used in creating a roadmap revealing the small number of aggressive cells that seed cancer’s often deadly migration.
A shared interest in evolutionary biology brought the research team together with colleagues at Cold Spring Harbor Laboratory to trace the trajectory of clonal populations of cancer cells from the primary tumor to metastatic sites such as the liver or bone. Their mission was to learn what special evolutionary adaptations permitted them to make the journey,...
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