pharmaphorum October 25, 2024
MSD has acquired Yale University spinout Modifi Biosciences, claiming ownership of a potential new class of therapeutics for difficult-to-treat brain tumours, including glioblastomas.
Under the terms of the deal, MSD (known as Merck & Co in the US and Canada) is paying $30 million upfront for Modifi, with up to $1.4 billion in milestone payments tied to the development of its drug candidates, which target cancer cells lacking expression of a DNA repair protein called O6-methylguanine methyl transferase (MGMT).
Approximately half of glioblastomas and more than two-thirds of grade II and III glioma tumours are deficient in MGMT.
Modifi was only formed in 2021 and its drug candidates are still in preclinical development, but the science behind them has been...
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