Inside Precision Medicine May 31, 2023
Organoids carve out a central role in precision medicine research, while developing clinical applications
The broad application of precision medicine has, until now, been largely hampered by the methods available to query the full complexity of humans and human disease. For instance, while immortalized cell lines have long been a workhorse of research in human biology, they are not able to reproduce the heterogeneity of diseases. In addition, the very process of immortalizing cells alters the fundamental biology of the tissue type they are derived from, and multiple propagations of cell lines introduce additional alterations. Mouse models, too, are limited, as they exhibit only a particular subtype of a disease and aren’t able to represent the diversity of disease phenotypes....
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